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Breaking News: The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza. One of the key peptides was made by LifeTein: HIF1a-P564: DLDLEMLAPYIPMDDDFQLR.

Highlights:

• Cell, 2019, A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
• Nature Communications, Volume 9, Article number: 4687 (2018), A structural mechanism for directing corepressor-selective inverse agonism of PPARγ
• Nature Communications, Article number: 1969 (2018) doi:10.1038/s41467-018-04390-7, Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus
• Nature Chemical Biology, Volume 14, pages 538–541 (2018), doi:10.1038/s41589-018-0054-z. Membrane association of monotopic phosphoglycosyl transferase underpins function
• Nature Communications, Volume 9, Article number: 607 (2018), Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds
• Nature, Available online on 17 January 2018, doi:10.1038/nature25442, Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling
• Cell, Available online 11 January 2018, LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer
• Science Advances, Park et al., Sci. Adv. 2018; 4: e1601453 12 January 2018, Membrane insertion of—and membrane potential sensing by—semiconductor voltage nanosensors: Feasibility demonstration
• Nature Scientific Reports, Article number: 14157 (2017), Connexin 43 Hemichannels Regulate the Expression of Wound Healing-Associated Genes in Human Gingival Fibroblasts
• Nature Communications, 8, Article number: 1403 (2017), Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease
• Cell, Volume 166, Issue 5, p1257–1268.e12, 25 August 2016, HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
• Cell, Volume 167, Issue 1, p248–259.e12, 22 September 2016, Portable, On-Demand Biomolecular Manufacturing
• Nature Communications, Published 25 July 2016, 7, Article number: 12276 doi:10.1038/ncomms12276, Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
• Nature Communications, Published 01 February 2016, 7, Article number: 10470 doi:10.1038/ncomms10470, Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
• Nature, 529, 172–177 (14 January 2016) doi:10.1038/nature16475, An ID2-dependent mechanism for VHL inactivation in cancer
• Cell, Volume 163, Issue 2, 8 October 2015, Pages 419–431, An Adaptor Hierarchy Regulates Proteolysis during a Bacterial Cell Cycle
• Nature Communications, 2015, Article number: 7443, doi:10.1038/ncomms8443, Pharmacological repression of PPARγ promotes osteogenesis
• Nature Scientific Reports, 2015, Article number: 9641, doi:10.1038/srep09641, Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain
• Cell, Volume 159, Issue 4, 6 November 2014, Pages 844–856, DOI: 10.1016/j.cell.2014.10.032. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis
• Nature Communications, Accepted 02 Aug 2014, doi:10.1038/ncomms5904, An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability
• Nature, Accepted 06 May 2014, doi:10.1038/nature13452, Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development
• Nature Materials, Accepted 14 April 2014, doi:10.1038/nmat3982, Etchable plasmonic nanoparticle probes to image and quantify cellular internalization
• Nature Communications, 5, Article number: 3571 doi:10.1038/ncomms4571, An alternate binding site for PPARγ ligands
• Nature, 497, 383–387, 2013, doi:10.1038/nature12080, EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
• Nature Communications, doi:10.1038/ncomms3261, Aug, 2013, Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion
• Biochemistry, 2013, DOI: 10.1021/bi401034q, Mechanistic Basis for the Potent Anti-angiogenic Activity of Semaphorin 3F
• PNAS, 2012, doi:10.1073/pnas.1119073109, Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
• Cell, 2012, Volume 151, Issue 6, 1243-1255, Piwi-Interacting RNAs Protect DNA against Loss during Oxytricha Genome Rearrangement
• Nature Immunology, 2011, doi:10.1038/ni.2107, The carboxypeptidase ACE shapes the MHC class I peptide repertoire
• Journal of Virology, 2013, doi: 10.1128/JVI.00814-13, Cross-inhibition of ChikunGunya virus fusion and infection by alphavirus E1 domain III proteins

	Nature, Accepted 06 May 2014, doi:10.1038/nature13452, Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development
	Nature Materials, Accepted 14 April 2014, doi:10.1038/nmat3982, Etchable plasmonic nanoparticle probes to image and quantify cellular internalization
	Nature Communications, 5, Article number: 3571 doi:10.1038/ncomms4571, An alternate binding site for PPARγ ligands
	Nature, 497, 383–387, 2013, doi:10.1038/nature12080, EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
	Nature Communications, doi:10.1038/ncomms3261, Aug, 2013, Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion
	Biochemistry, 2013, DOI: 10.1021/bi401034q, Mechanistic Basis for the Potent Anti-angiogenic Activity of Semaphorin 3F
	PNAS, 2012, doi:10.1073/pnas.1119073109, Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
	Cell, 2012, Volume 151, Issue 6, 1243-1255, Piwi-Interacting RNAs Protect DNA against Loss during Oxytricha Genome Rearrangement
	Nature Immunology, 2011, doi:10.1038/ni.2107, The carboxypeptidase ACE shapes the MHC class I peptide repertoire
	Journal of Virology, 2013, doi: 10.1128/JVI.00814-13, Cross-inhibition of ChikunGunya virus fusion and infection by alphavirus E1 domain III proteins

Srinivasan, P. et al. Disrupting malaria parasite AMA1–RON2 interaction with a small molecule prevents erythrocyte invasion. Nat. Commun. 4:2261 doi: 10.1038/ncomms3261 (2013).

Biotin-RON2, a synthetic biotinylated 42 mer peptide, was synthesized by LifeTein. Synthetic peptides are crucial in the process of understanding protein-protein interactions. Using a high throughput screen method, Prakash Srinivasan assessed the inhibitors that block interactions between AMA1-RON2. He shows that the inhibitor binds to AMA1 and prevents its interaction with RON2. Such inhibitors of merozoite invasion used in combination with existing antimalarials hold great promise as a novel therapeutic approach in the fight against malaria.

... Biotin-tagged RON2 peptide(DITQQAKDIGAGPVASCFTTRMSPPQQICLNSVVNTALSTSTQSAMK) with the two cysteines cyclized was synthesized and purified (95% pure) by LifeTein, LLC USA (New Jersey, USA) ...

ET Smith, DA Johnson, Protein Science, 2013, Human enteropeptidase light chain: Bioengineering of recombinants and kinetic investigations of Structure and function, DOI: 10.1002/pro.2239

Synthetic peptides by LifeTein were used as substrate to study the protein structure and function. ET Smith and DA Johnson found that the positively charged peptides could contribute the substrate specificity in human enteropeptidase. It shows importance of the charge-charge interactions in the substrate binding pocket. For example, peptide DDDDK and DDDDR could have different specificities for substrates.

... The extended peptide substrates GD4K-pNA and GD4R-pNA (LifeTein) were used at concentrations between 0.02-1.0 mM and 5-100 µM, respectively. Reactions were initiated by adding enzyme to ...

Paul M. Arnaboldi, et al. An outer surface protein C (OspC) peptide derived from Borrelia burgdorferi sensu strico as a target for the serodiagnosis of early Lyme disease, Published ahead of print 30 January 2013, doi: 10.1128/CVI.00608-12

LifeTein advanced the research on serodiagnostic assays for Lyme disease. The linear epitopes OspC1 was synthesized by LifeTein. This highly conserved 20 amino acid peptide epitope detected specific IgM and/or IgG in 60 out of 98 serum samples. This OspC1 peptide could have value as a component of a multi-peptide Lyme disease serological assay with significantly improved capabilities for the diagnosis of early infection. OspC1 was proved to have higher specificity than the commercial available OspC peptide.

... A positive signal was required to be at least 4x the FSI of the negative assay control. Peptides chosen for further analysis were produced by Lifetein, Inc. (South Plainfield, NJ), and were a minimum of 90% purity. ...